4.6 Regulation of the Cell Cycle
in AP Biology
Levels of proteins called cyclins increase and decrease during the cell cycle. Cyclins were discovered in studies of mitosis in sea urchin gametes.
To Think About:
What are cell cycle checkpoints? What is the role of checkpoints in regulating the cell cycle? How are proteins are involved in checkpoints? What happens if the cell cycle is disrupted?
Watch: AP Daily Video Regulation of the Cell Cycle
Answer the Following Questions:
- What are four things that are “checked” at the G1 checkpoint?
- What are three things that are “checked” at the G2 checkpoint?
- Name a major event that is “checked” at the M-spindle checkpoint.
- What is the function of cyclins? Why do you think they were named “cyclins”?
- What is the function of cdks? How are they activated?
- If the cell cycle occurs too quickly, _______________ can result.
- Why might a cell go through apoptosis?
- Place the following events in the cell cycle in the proper order: a. Anaphase b. Cytokinesis c. G2 d. Telophase e. G1 f. Prophase g. S h. Metaphase
Supplementary Resources:
- Khan Academy: Cell cycle control
- Medicosis Perfectionalis: Checkpoints of the Cell Cycle
- Neural Academy: p53 Tumour Suppressor and MDM2
